In the population hospitalized for DFU sepsis in 2008–2013 and in 2014–2019 periods, arterial hypertension (p = 0.011), dyslipidemia (p<0.001), mild chronic kidney disease (p = 0.013), mild, moderate non-proliferative and proliferative retinopathy (all p<0.001), oral hypoglycaemic agents (p = 0.013), combined oral hypoglycaemic agents and long-acting insulin (p = 0.016), revascularization treatment (p = 0.026) were more frequent in the 2008–2013 than 2014–2019 periods (Table 3). This evidence concerns the gene INS and metabolic syndrome.