On the other side, stroke (p = 0.004), current (p<0.001) and former smoking (p<0.001), peripheral vascular disease (p = 0.001), basal bolus insulin (p<0.001), ischemic lesions (p = 0.013), osteomyelitis (p = 0.015), minor amputations (p = 0.019) were less frequent in the period 2008–2013 than 2014–2019 (Table 3). This evidence concerns the gene INS and peripheral vascular disease.