Among patients hospitalized in the period 2008–2013, dead patients have higher frequency of moderate (p = 0.016) and severe chronic kidney disease (p = 0.001), peripheral vascular disease (p = 0.005), basal-bolus insulin therapy (p = 0.022) and lower frequency of oral hypoglycaemic therapy (p = 0.048) and neuropathic lesion (p = 0.031) than living patients (S1 Table). This evidence concerns the gene INS and peripheral vascular disease.