We observed increased expression of intracellular IFN-γ in NK cells, CD4+ T cells, and CD8+ T cells from Alk1fl/flVav1Cre mice 24 hours after infection (Supplemental Figure 10A), which coincided with higher bacterial counts in the livers and spleens of Alk1fl/flVav1Cre mice than in Alk1fl/fl mice (Supplemental Figure 10B). The gene discussed is CD8A; the disease is infection.