In addition, whereas no patients (or only a small proportion) harbored PD-L1–vInt4 expression in approximately two-thirds of all cancer types, as much as 10%–20% of patients with squamous cell carcinoma, including LUSC, head and neck squamous cell carcinoma (HNSCC), and cervical squamous cell carcinoma, expressed PD-L1–vInt4 (Figure 3A). This evidence concerns the gene CD274 and squamous cell carcinoma.