We subsequently determined that (a) Perp expression was significantly decreased in tumors from 3-MA–treated KPC mice compared with vehicle-treated controls (Figure 5C), (b) Perp was reduced in the tumor and the muscles of PDO mice treated with 3-MA (Supplemental Figure 6A), and (c) Perp was increased in skeletal muscle samples from young and aged tumor-bearing mice (Supplemental Figure 6B). Here, PERP is linked to neoplasm.