In line with this possibility, treating epithelial 393P cells or human lung cancer HCC827 cells with the DNA methyltransferase inhibitor 5-azacytidine or the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) significantly upregulated Itga1 levels (Figure 4A and Supplemental Figure 4A). The gene discussed is HDAC9; the disease is lung carcinoma.