The most well-known phenotype is the eponymous Stargardt disease (STGD1, MIM #248200; ref. 2); however, advances in genetic screening capabilities, aided by high-resolution diagnostic imaging technology, have broadened the phenotypic profile of ABCA4 disease to an expansive clinical spectrum encompassing severe adolescent-onset to mild late-onset retinal disorders (3). This evidence concerns the gene ABCA4 and retinal disorder.