SOX18 and neoplasm: Overman et al. demonstrated that propranolol can act independently of its effect on β-adrenergic receptors by disrupting dimer formation of the transcription factor SRY (sex-determining region Y) box transcription factor 18 (SOX18) (23), which plays an important role in endothelial cell (EC) differentiation during blood vessel development (24, 25) as well as tumor-induced angiogenesis (26).