The maximum dose of 2 × 12.5 mg/kg/day in mice is the animal-equivalent dose of 2 mg/kg/day propranolol in humans (32) and has shown an almost complete rescue of the vascular phenotype in a murine model of hypotrichosis-lymphedema-telangiectasia syndrome and renal syndrome caused by a SOX18 mutation (25 mg/kg/day was given once a day in the Ragged Opossum mouse model) (23). Here, SOX18 is linked to hypotrichosis.