In this study, the results of the correlation analysis on mTOR and Ki-67 expressions in CSCC, BD, and AK revealed that the expression level of mTOR was positively correlated with that of Ki-67 in CSCC, BD, and AK, demonstrating that mTOR is related to the proliferation degree of CSCC, and the higher the proliferation level of squamous cells, the higher the positive expression level of mTOR. The gene discussed is MTOR; the disease is skin squamous cell carcinoma.