In terms of specific biomarkers, CALD1 stroma and POSTN tumour positivity was much greater amongst CRLM versus paired primary CRC (93.5% vs. 20%, p < 0.001 and 72.6% vs. 12.7%, p < 0.001, respectively), and POSTN stroma and TGF‐β tumour positivity was much less (6.5% vs. 85.5%, p < 0.001 and 15.3% vs. 83.6%, p < 0.001, respectively). Here, POSTN is linked to colorectal carcinoma.