This study firstly aimed to validate the prognostic significance of proteins CALD1, IGFBP7, POSTN, FAP, TGF‐β (product encoded by the gene TGFB1) and pSMAD2 in primary CRC and similarly assess these biomarkers in CRLM by IHC with a view towards clinical application. Here, IGFBP7 is linked to colorectal carcinoma.