Furthermore, IL‐5 and IL‐13 are important CD4 T‐cells and ILC2‐derived cytokines that are involved in eosinophilia, mucus production, and airway hyperreactivity, and they have been suggested as biomarkers and therapeutic targets for type‐2 inflammation‐related disorders such as allergic asthma.42, 43, 44, 45. This evidence concerns the gene CD4 and Irritability.