TNF and Crohn disease: As for Crohn’s disease, since antitumor necrosis factor (TNF) antibody infliximab functioned as an inducer of activated lamina propria T lymphocyte apoptosis, it was not surprising that imaging apoptosis by 99mTc-Annexin V SPECT/CT in patients suffering from inflammatory bowel disease may help predict the efficacy of anti-TNF therapy [46].