Compared with the imaging results of 18F-FDG and 11C-PIB, 11C-DED images showed a prominent increase in MAO-B in the early stage of clinical symptom onset (Fig. 2), which strengthens the possibility the activation of astrocytes may be an early driving force of Alzheimer’s disease pathology [50]. Here, MAOB is linked to early-onset autosomal dominant Alzheimer disease.