The expression of phosphorylated mammalian target of rapamycin complex 1 (p-mTORC1), the upstream regulator of RPS6 is also increased in PCa tissues and correlates with a high expression of p-RPS6 and p70 RPS6 kinase 1 (p70S6K1) as shown by IHC analysis [53]. Here, RPS6KB1 is linked to posterior cortical atrophy.