The knockdown of RPS15A by shRNA in breast cancer cell line ZR-75-30 and BT474 mediates apoptosis via the activation of caspase-3 and PARP cleavage, the up-regulation of Bad and BAX and the down-regulation of Bcl-2 confirming the importance of RPS15 in the modulation of breast cancer development [63]. The gene discussed is BCL2; the disease is breast carcinoma.