RPS7 is also down-regulated in colon cancer and its overexpression is correlated with good prognosis as it suppresses hypoxia-inducible transcription factor-1α (HIF-1α), metabolic promoting proteins glucose transporter 4 (GLUT4) and lactate dehydrogenase B (LDHB) both in vitro and in vivo [40]. The gene discussed is LDHB; the disease is malignant colon neoplasm.