This study found that interference with lncRNA FOXD2-AS1 can reduce p-PI3K and p-AKT protein expression levels, thereby inhibiting the PI3K/AKT signaling pathway, revealing that lncFOXD2-AS1 can increase protein expression levels of p-PI3K and p-AKT in breast cancer cells. This evidence concerns the gene AKT1 and breast carcinoma.