GFER and neurodegenerative disease: Using the brain-specific coexpression matrix, however, we found a strong enrichment of HPO terms that are related to ALS or neurodegenerative diseases in general, including ‘cerebral cortical atrophy’ (P = 1.8 × 10−8), ‘abnormal nervous system electrophysiology’ (P = 4.1 × 10−7) and ‘distal amyotrophy’ (P = 8.6 × 10−7; full list in Supplementary Table 22).