Our findings might thus provide the missing link as to why SOCS3 mRNA and protein expression are low in T-LGL leukemia, as indicated by Teramo et al. in 2013 [6]Furthermore, these findings also reveal why STAT3 nonmutated patients also bear hyper-activation of the STAT3 molecule. This evidence concerns the gene SOCS3 and T-cell large granular lymphocyte leukemia.