We identified that the overexpression of one particular miRNA, miR-181a, which results in hyperactive STAT3 and ERK1/2 by decreasing SOCS3 and DUSP6 expression in T-LGL leukemia patient cells, eventually leads to resistance to FAS-mediated apoptosis. This evidence concerns the gene SOCS3 and T-cell large granular lymphocyte leukemia.