Since ERK1/2 and especially STAT3 are known to be involved in survival of T-LGL leukemia cells through inhibition of FAS-mediated apoptosis, TL1 cells were transfected with 25 nM LNA miR-181a inhibitor and 48 h post transfection cells were incubated overnight with the agonistic CD95 antibody to evaluate apoptosis. The gene discussed is FAS; the disease is T-cell large granular lymphocyte leukemia.