Regions with IDHmut-specific hypermethylation were enriched for active enhancers, many of which formed direct interactions with highly expressed AML genes, including MYC and ETV6. Although increased methylation at these loci was not associated with repressed chromatin or lower gene expression in IDHmut AML samples, this finding demonstrates that IDHmut-associated hypermethylation affects the regulatory sequences of genes that may contribute to AML pathogenesis. The gene discussed is ETV6; the disease is acute myeloid leukemia.