IDH2 and acute myeloid leukemia: AML samples with either DNMT3AR882 or IDH mutations (and some with TET mutations) formed sub-clusters on opposite sides of the main AML group, which is consistent with the hypomethylation phenotype of AML cells with the DNMT3AR882 mutation [5] and suggests IDHmut samples may also have unique methylation features compared to other AMLs.