Further analysis of 3D genome interactions containing IDHmut-specific DMRs identified known and novel enhancers of genes important in hematopoiesis and AML, including an enhancer of MYC [40–42] (Fig. 6E), and previously unreported putative enhancers that form interactions with ETV6 (Fig. 6F), DOT1L, and SRSF3 (Fig. S6E, F). The gene discussed is DOT1L; the disease is acute myeloid leukemia.