IDH2 and acute myeloid leukemia: To assess whether de novo DNA methylation by DNMT3A contributes to IDHmut-associated hypermethylation, we analyzed methylation levels at IDHmut-specific DMRs in seven AML samples with co-occurring IDH1 (N = 5) or IDH2 (N = 2) and DNMT3AR882 mutations (R882 mutations have a more severe hypomethylation phenotype than other DNMT3A mutations [4, 39]).