IDH2 and acute myeloid leukemia: IDHmut AMLs also tended to have higher mean methylation vs. other AML groups both genome-wide (Fig. 1E, adjusted P = 0.02) and in regions with other chromatin states (Figs. S1A, B), but not in CGIs (Fig. 1F; P = 0.14), indicating that IDH mutations do not result in an exaggerated CGI hypermethylation phenotype.