The remaining genes are less characterized in EC tumors but have interesting roles in other cancers related to transcriptional regulation (PBX1 interacts with the estrogen-axis in breast cancer39 and SAT1 functions as a transcriptional regulator in aggressive brain tumors40), and key signaling pathways including the transforming growth factor β (TGFβ) pathway (GDF1541), the PI3K/AKT-pathway (ANX1A42), and the Mitogen-activated protein kinase (MAPK) pathway (CNDP243). This evidence concerns the gene AKT1 and cancer.