We found that prior to HIV infection, mucosal IgG subclasses and isotypes were positively and significantly associated with several inflammatory cytokines: TNF-α, IL-1α, IL-1β, IL-10 and IL-6; adaptive cytokines: IL-13, IL-4 and IFN-γ and chemotactic and growth factors: MIP-1α, MIP-1β, MCP-1, IL-8, CTACK and MIG after adjusting for potential confounders. The gene discussed is IL1A; the disease is HIV infectious disease.