NPPA and infection: Adult BALB/c mice were infected intraperitoneally with Kp-1705, a virulent hypermucoid strain of K. pneumoniae (Methods) which results in rapid bacterial dissemination to blood, spleen, and other solid organs (liver, lungs, and kidneys; 106–108 CFU/g) within 1 h of infection (Supplemental Data Fig. 1).