In GR-knockdown or mifepristone-treated HY24409 pancreatic tumors, knockdown of B2M depleted surface MHC-I in vivo (Fig. 5f, g), decreased the percentages of tumor-infiltrating CD8+ T cells and granzyme B+ CTLs (Fig. 5h–k), and rescued tumor growth (Fig. 5l–q). Here, NR3C1 is linked to pancreatic neoplasm.