Specifically, knockdown of GR increased the percentages of tumor-infiltrating CD8+ cells and granzyme B+ CTLs by 4.6-fold and 2-fold (Fig. 4c, d), while treatment with mifepristone increased the percentages of tumor-infiltrating CD8+ cells and granzyme B+ CTLs by 1.9-fold and 1.6-fold (Fig. 4e, f). The gene discussed is GZMB; the disease is neoplasm.