Strikingly, shRNA-mediated knockdown of GR in HY24409 cells rendered otherwise ICB-resistant orthotopic pancreatic tumors highly sensitive to dual ICB treatment (Fig. 6a–d and Supplementary Fig. 6a), without causing body weight loss (Supplementary Fig. 6b), which underscores a tumor cell-specific role of GR in regulating immunotherapeutic response. The gene discussed is NR3C1; the disease is neoplasm.