NR3C1 and pancreatic neoplasm: In contrast, in C57BL/6 mice, either GR knockdown in HY24409 cells (Fig. 3a–e) or systemic mifepristone treatment (Fig. 3f–j) led to substantial reductions in orthotopic pancreatic tumor volume (gauged by magnetic resonance imaging) and weight, without significant loss of body weight (Supplementary Fig. 3o, p).