NR3C1 and Immunodeficiency: To determine the functional role of GR in pancreatic cancer cells, we implanted either NSG (non-obese diabetic; severe combined immunodeficiency; interleukin-2 receptor gamma chain null) mice or immunocompetent C57BL/6 mice with two mouse PDAC cell lines (HY24409 and HY24160), both of which were derived from male KPC (p48-Cre;KrasLSL-G12D/+;Trp53loxP/+) mice34,35 that were backcrossed to the C57BL/6 background (the purity of the C57BL/6 background of the mice used for KPC cell line generation was approximately 98% based on SNP analysis).