CD274 and familial pancreatic carcinoma: To further corroborate the role of GR in regulating PD-L1 and MHC-I expression levels in pancreatic cancer cells, we knocked down GR in SU86.86 and SW1990 cell lines by two independent shRNAs, finding that silencing of GR significantly downregulated PD-L1 and upregulated MHC-I and B2M at both mRNA and protein levels (Fig. 1g–k and Supplementary Fig. 1g, h).