Consistent with the observed anti-tumor effect of GR knockdown or inhibition in immunocompetent mice, either GR-depleted or mifepristone-treated pancreatic tumors showed lower cell-surface PD-L1 levels as well as higher cell-surface MHC-I (H-2Kb) and B2M levels, as gauged by flow cytometric analysis (Fig. 4j, k and Supplementary Fig. 4d, e). The gene discussed is CD274; the disease is neoplasm.