CD4 and myeloid sarcoma: As a result, we (1) provide a genome-wide cis- DNA methylation QTL (mQTL) map of CD4+ T cells in MS patients, which can be utilized in future studies of MS and other inflammatory diseases, (2) identify cis- effects of MS genetic susceptibility variants on nearby CpG dinucleotide methylation, (3) discover and validate a trans-mQTL effect of an MS variant, and (4) demonstrate that polygenic scores of MS susceptibility influence DNA methylation at specific CpG dinucleotides and suggest the convergence of the effects of multiple variants on methylation levels in distal CpG sites.