Second, in a series of analyses focused on MS, we identified not only the cis effects of individual MS susceptibility loci but also robust evidence for trans effects: (a) the MS locus near TBX6 on chromosome 16 influences methylation of a CpG island in the PRDM8 gene on chromosome 4, and (b) the MHC polygenic score affects methylation of an enhancer of PRKCA on chromosome 17. This evidence concerns the gene PRKCA and myeloid sarcoma.