For example, multiple genes in the AT1 cell program were closely related to pulmonary veno-occlusive disease (PVOD) (Bmpr2 and Eif2ak4), lung cancer (Itga9 and Braf), pulmonary fibrosis (Cadm1 and Itgb6), pulmonary hypertension (Bmpr2 and Cav1), and pulmonary emphysema (Itgb6). This evidence concerns the gene BRAF and pulmonary arterial hypertension.