PDXDC2P and Abnormality of the thyroid gland: In addition, we found four loci associated with both the salivary microbiome and metabolic traits or diseases at genome-wide significance: DPEP2/NFATC3 that associated with species Lancefieldella sp000564995 was linked to high-density lipoprotein cholesterol (HDLC); PDXDC2P-NPIPB14P associated with species Centipeda sp000468035 linked to thyroid abnormality; LARP1 associated with species Aggregatibacter kilianii linked to mean corpuscular hemoglobin; SMARCA1 associated with species Veillonella parvula linked to pharyngeal mucosal congestion (PMC) (Supplementary Fig. S8).