Interestingly, the three upregulated pathways in SCLC (E2F_Target, G2M_checkpoint, and MYC_target) were associated with cell proliferation, while six of the nine downregulated pathways in SCLC components (IL2, complement, INFG, INFA, TNFA, and inflammatory response) were associated with inflammatory/immune response. This evidence concerns the gene TNF and small cell lung carcinoma.