Among lung cancers, for example, alterations in EGFR, KRAS, SMARCA4, STK11, and KEAP1 are almost exclusively observed in LUADs24; LUSCs often carry mutations in TP53, CDKN2A, RB1, NFE2L2, KEAP1, PIK3CA, and PTEN25, while RB1 and TP53 are frequently altered in neuroendocrine carcinomas (NEC) including LCNEC and SCLC26. The gene discussed is RB1; the disease is lung cancer.