TNF and COVID-19: Furthermore, elevated cytokine levels (IL-1β, INF-γ, TNF-α, and IL-6),19–24,36 which are also closely related to the function of lymphocytes or monocytes, are critical change in COVID-19 and can cause severe cytokine storm and death.9 Damaged regulatory function in T cells can be an important factor responsible for the abnormal production of cytokines.