ACE2 and infection: To evaluate the importance of MYH9 in SARS-CoV-2 infection in pulmonary epithelial cells, we depleted ACE2 in PRA-A549 cells and found that the infection with SARS-CoV-2 was significantly decreased, suggesting that MYH9 might not act as a virus receptor alone and that low ACE2 expression is required for MYH9-mediated SARS-CoV-2 infection (Fig. 4F).