Compared with ORMDL3− cholangiocytes, we found 77 significant DEGs among ORMDL3+ cholangiocytes, which contain numerous cytokine and chemokine genes, such as CXCL8, CCL3, and CXCL1, that may involve in mediating the immune-regulation for PBC risk. The gene discussed is CXCL8; the disease is primary biliary cholangitis.