Among them, 10 genes, including IRF5 [5, 6, 8, 9], SOCS1 [5], SYNGR1 [5, 7], ORMDL3 [7, 9, 33], MANBA [5], IDUA [5], DGKQ [5], FCRL3 [40], NAAA [41], and SH2B3 [5], have been documented to be associated with PBC. Here, IRF5 is linked to primary biliary cholangitis.