ORMDL3 and cholangitis: Based on the liver expression profiles generated from healthy mice (n = 4) and mice suffering from cholangitis (n = 6) from the GEO database (GSE179993), we performed a differential gene expression analysis and found that the ORMDL3 gene was significantly higher expressed among cholangitis-affected mice than that among healthy age- and sex-matched mice (P = 0.036, Additional file 1: Fig. S14).