In all patients, the univariate analysis revealed factors associated with poor outcomes, including having a chronic onset (P = 0.0002), an elevated CSF protein level (P = 0.0075), tumours (P < 0.0001), no relapse (P = 0.0081), PNS (P = 0.0004), higher levels of serum CXCL10 (P = 0.0258) and serum BAFF (P = 0.0409) (Table 2). This evidence concerns the gene TNFSF13B and neoplasm.