SHBG and chronic hepatitis B virus infection: Considering the dynamic transformation between the bound and free forms of testosterone, interactions between steroid hormones and the potential influences of sex, age, body mass index (BMI), and other clinical factors, we sought to compare the circulating serum levels of total testosterone (TT), free testosterone index (FTI), sex hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and androstenedione (AND) in men with HBV-ACLF with those of age- and BMI-matched chronic hepatitis B patients and healthy controls without liver disease.