In addition, the role of FOXD2-AS1 in HNSCC was also related to the p53 signaling pathway, and the p53 signaling pathway plays a part in the regulation of expression of several genes and is closely related to the development of human tumors, whose activation initiates cell cycle arrest as well as DNA repair, and inhibits proliferation of OSCC cells [38]. Here, FOXD2 is linked to head and neck squamous cell carcinoma.