It was speculated that by regulating SHP-1 and c-Src, Ang-(1-7) activated the activity of proteins related to the protein kinase signaling pathway (ERK1/2, Akt, and p38MAPK) and downregulated the expressions of TGF-β/MMP-2/TIMP-1/collagen I, to antagonize AngII induced atrial fibrosis remodeling, thereby ultimately play a protective role in atrial fibrillation. This evidence concerns the gene MAPK3 and atrial fibrillation.