As the direction of research has expanded, some reports have shown that the SPARCL1 gene has additional physiological functions, e.g, SPARCL1 inhibits adipogenesis in 3T3-L1 cells [16]; SPARCL1 is highly upregulated in adipose tissue in patients with non-alcoholic steatohepatitis [B. 19, 20]. The gene discussed is SPARCL1; the disease is metabolic dysfunction-associated steatohepatitis.