PLOD1 and Ovarian Hyperandrogenism: The increase in body weight is the main determinant of insulinemia, insulin sensitivity, and ovarian hyperandrogenism.18Therefore, women who are overweight or obese may have altered endocrine profiles such as high LH, abnormal ratio of FSH and LH, low progesterone in the luteal phase, and low levels of sex hormone-binding globulin.19