Previous genetic studies in mice have demonstrated that CMG-2 deficiency conferred far greater resistance to anthrax lethal toxin and B. anthracis spore exposure than TEM-8 deficiency and identified the heart and liver as key CMG-2-dependent targets for, respectively, anthrax lethal toxin and anthrax edema toxin (12, 52). This evidence concerns the gene ANTXR2 and anthrax infection.