We noted that while APC is only mutated in a substantial proportion of COAD samples, it is significantly hypermethylated in COAD along with several other cancer types (BLCA, BRCA, LIHC, LUAD, PRAD and UCEC), being hypermethylated in 50% of samples or more in several tumour types (Figure 6B). This evidence concerns the gene APC and cancer.