Similarly, we also found strong correlations of GSTM2 and GSTP1 promoter methylation with copy number alteration (CNA) burden in prostate cancer (Spearman’s ρ of 0.53 for GSTM2 and 0.49 for GSTP1; Supplementary Figure S7D and E), with both promoters among the promoters whose methylation is most strongly associated with CNA burden (Supplementary Figure S7F). Here, GSTM2 is linked to Familial prostate cancer.