We tested the top 10 most frequently mutated genes in PRAD and found that both TP53 and FOXA1 displayed increased mutation frequencies in the top quartile of samples ranked by GSTP1 promoter methylation compared to the bottom quartile (FOXA1 P-value = 0.0002; TP53 P-value = 0.026; both Fisher’s exact test). The gene discussed is TP53; the disease is prostate adenocarcinoma.