There were several chromatin modifiers also among the hypomethylated genes, including the histone acetyltransferase NCOA1 in four cancer types, the histone deacetylase HDAC9 in two cancer types, and the histone demethylases KDM1A, KDM2A, KDM4A, KDM6B and the histone methyltransferase KMT5C in one cancer type each. The gene discussed is PRDM9; the disease is cancer.