PPARGC1B and infection: Attempts to explore the role of B-1 and B-2 cells utilizing B cell deficient muMT mice were complicated by their high susceptibility to primary infection with the CEP strain, irrespective of whether they received PerC as neonates or splenic B-2 cells prior to the primary infection (S6C–S6E Fig), thus underscoring the importance of B cells in resistance to T. gondii infection [13].