We carried out HLM calculation for a 1.28-Mb genomic region on chromosome 8, which contains 13 CTCF-binding sites, for both wild-type (WT) and WAPL-deficient (ΔWAPL) human chronic myeloid leukemia (HAP1) cells, whose triplet contacts were measured with MC-4C [18]. Here, WAPL is linked to chronic myelogenous leukemia, BCR-ABL1 positive.