CDHR5 and deafness: In addition, a mutation in CDHR5, p.R84G (residue numbering throughout the text corresponds to processed proteins, see Methods), which mimics a deafness-related mutation in PCDH15, interferes with the intermicrovillar links formed by PCDH24 and CDHR5 [9], suggesting that these proteins interact in a similar fashion to the heterophilic tip-link “handshake” formed by CDH23 and PCDH15 [32,36,37].