IGHE and anaphylaxis: However, both the allergic characteristics of the patient receiving the transfusion and the cellular and plasma components of the transfusion products can contribute to the development of ATRs,[3] specifically type 1 hypersensitivity reactions in which immunoglobulin E (IgE) interacts with components in the donor plasma.[3] Manifestations vary from mild allergic reactions to severe anaphylaxis.