JAK2 and acquired polycythemia vera: Different treatment modalities have been used for pruritis control in PV, including antihistamines, interferon-alpha, phototherapy, phlebotomy, and cytoreductive therapy; however, all of them demonstrated a mixed result.[4] Recently, Ruxolitinib, a JAK2 inhibitor, has been shown to be very effective in the treatment of PV-related pruritis, especially treatment-resistant cases.[5] In this case, we describe a PV patient who presented with severe itching, especially after showering.