Meta-analysis is a useful tool for the detection of disease–gene relationships.[16] In the Chinese Han population, 1 meta-analysis showed no association between the RGS4 gene and the risk of schizophrenia[15]; however, in another meta-analysis, the SNP, rs951436, was found to be associated with the risk of schizophrenia.[17] Therefore, the association between RGS4 and the risk of schizophrenia remains complicated and controversial.[17–19] Additional articles have since been published; thus, an updated meta-analysis is needed. Here, RGS4 is linked to schizophrenia.