As a possible therapeutic target, it plays an important role in improving glaucoma and protecting eyesight.[43,44] MCT8 is a thyroid hormone transporter with high affinity for T4 and T3.[21] The mutation of MCT8 is the reason for severe X-linked psychomotor retardation and cause a severe neurodevelopmental disorder.[45] Research about the mechanism of MCT8 and MCT2 deficiency, improving treatment strategies, and screening target drugs is another meaningful development trend.[46,47]. This evidence concerns the gene SLC16A2 and neurodevelopmental disorder.