CXCL3 and head and neck squamous cell carcinoma: CCK8 was used to detect the role of CXCL3 in the proliferation of HNSCC cells, and the results showed that up-expression of CXCL3 promotes the proliferation of CAL27 cells, while down-expression of CXCL3 significantly inhibits the proliferation of HSC-4 cells (Figure 7A).