In the present study, we finally, using Western blot experiments, identified that overexpression of CXCL3 in HNSCC cells regulate the expression of several important proteins including Bax, Bcl-2, p-ERK, NF-κB, p-STAT3, and STAT3 in above-mentioned pathways. Here, STAT3 is linked to head and neck squamous cell carcinoma.