After interacting with its cell surface receptor CXCR2, CXCL3 is participated in regulating numerous physiological and pathological processes, such as chemotaxis, angiogenesis, pregnancy-related diseases, tumors, cardiovascular diseases and lung diseases by regulating the processes of cell migration, invasion, angiogenesis, and fibrosis [14–18]. This evidence concerns the gene CXCL3 and cardiovascular disorder.