Our findings also revealed that CXCL3 contribute to the malignant behaviors of HNSCC cells through several tumor related signaling pathways including Toll-like receptor, Nod-like receptor, Jak-STAT and MAPK signaling pathways, suggesting that CXCL3 may play a crucial role in the occurrence and development of HNSCC. This evidence concerns the gene SOAT1 and head and neck squamous cell carcinoma.