GSEA analysis was used to perform KEGG analysis on the CXCL3 gene in the TCGA HNSCC set, with P<0.05, FDR<0.25 as the standard, and ranking in descending order of enrichment value from high to low, and selecting the most enriched signal pathway. The gene discussed is CXCL3; the disease is head and neck squamous cell carcinoma.