Whereas these malignant behaviors of HNSCC cells were decreased after down-regulating CXCL3 expression At the same time, we found that the high CXCL3 expression was associated with apoptosis, Toll-like receptor signaling pathway, Nod-like receptor signaling pathway, Jak-STAT signaling pathway, and MAPK signaling pathway by GSEA. Here, CXCL3 is linked to head and neck squamous cell carcinoma.