CXCL3 and head and neck squamous cell carcinoma: In the present study, we found that the copy number of the CXCL3 gene in HNSCC tissues increased, and the main types of CXCL3 gene alteration were mRNA High, amplification, and missense mutation, suggesting that CXCL3 expression may be related to the poor prognosis of patients with HNSCC.