However, several proteins were altered among the NCL subtypes, including HEXA (increased in patients diagnosed with CLN1, CLN3 and CLN5 disease, and in some patients diagnosed with CLN2 and CLN6 disease), LAMP1 (increased in patients diagnosed with CLN3 and CLN5 disease, and in some patients diagnosed with CLN2 disease), GOT1 (increased in patients diagnosed with CLN3 and CLN5 disease, and in some patients diagnosed with CLN2 disease), and TPP1 (reduced in all NCL subtypes). The gene discussed is NUCLEOLIN; the disease is CLN5 disease.