APOE and early-onset autosomal dominant Alzheimer disease: In addition, increased levels of adiponectin have been reported in CSF from patients diagnosed with multiple sclerosis (Hietaharju et al., 2010) or Alzheimer's disease (Une et al., 2011), and APOE is associated with a genetic predisposition to late-onset Alzheimer's disease (Burke and Roses, 1991-1992).