As presented in Table 2, it could be observed that serum CASC15 level in NS patients presents a significant positive correlation with the patients’ relevant clinical indicators, such as WBC, CRP, PCT, IL-6, IL-8, and TNF-α (all P< 0.01), showing that the level of CASC15 was correlated with the severity of NS. The gene discussed is CXCL8; the disease is Netherton syndrome.