To determine how β-arrestin–biased AT1R signaling affects hemodynamics in PAH, we treated MCT PAH rats 1 week after MCT injection with minipumps of PBS, AngII, TRV023, or losartan for 2 weeks followed by an analysis of hemodynamics with RV PV loop analysis (Figure 1E). Here, AGTR1 is linked to pulmonary arterial hypertension.