INS and gestational diabetes: By conducting a validation study in 10 GDM pregnant women compared with 10 healthy subjects of normal glucose tolerance, they further confirmed that the level of miR-222 was negatively correlated with the protein concentration of transporter glucose transporter 4 (GLUT4) in omental adipose tissue, as well as estrogen receptor- (ER-) α; the implication of the latter was validated in glucose homeostasis and insulin regulation [70–72].