Overall, the OD values in our ELISA test of AO, TF, and C5 were significantly higher in cattle resistant to bTB than in those with bTB (≥1.4x, ≥1.7x, ≥1.7x, respectively), regardless they were suffering or not from other unrelated infectious or metabolic diseases (p < 0.001). Here, TF is linked to metabolic disease.