For mitochondrial autophagy, one study reported that the renovascular hypertension model for domestic pigs improved left ventricular hypertrophy by reducing the myocardial LC3-II/LC3-I ratio and colocalization of Parkin and Tomm20, suggesting that ARB suppressed LC3-dependent mitochondrial autophagy (36). This evidence concerns the gene MAP1LC3A and left ventricular hypertrophy.